Endothelium-derived relaxing factor, nitric oxide: effects on and production by mesangial cells and the glomerulus.
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چکیده
منابع مشابه
Endothelium-derived relaxing factor, nitric oxide: effects on and production by mesangial cells and the glomerulus.
The endothelium-derived relaxing factor nitric oxide (EDRF/NO) is a labile, endogenous vasodilator that is important in the control of systemic vascular tone. This review focuses on the effects of EDRF/NO on glomerular mesangial cells in vitro and on the role of EDRF/NO in mesangial and glomerular physiology and pathophysiology in vivo. It was concluded that EDRF/NO can stimulate increases in c...
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Atropine has been used to block cholinergic neurotransmission in basic research. Large doses of atropine cause vasodilation of the blood vessels in the skin. This effect is apparently unconnected with the antimuscarinic activity of atropine and seems to be due to a direct action on the blood vessels. It has been suggested that atropine blocks muscarinic receptors at low doses and it induces th...
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atropine has been used to block cholinergic neurotransmission in basic research. large doses of atropine cause vasodilation of the blood vessels in the skin. this effect is apparently unconnected with the antimuscarinic activity of atropine and seems to be due to a direct action on the blood vessels. it has been suggested that atropine blocks muscarinic receptors at low doses and it induces the...
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S-nitrosothiols may serve as carriers in the mechanism of action of endothelium-derived relaxing factor (EDRF) by stabilizing the labile nitric oxide (NO) radical from inactivation by reactive species in the physiological milieu and by delivering NO to the heme activator site of guanylyl cyclase. Low-molecular-weight thiols, such as cysteine and glutathione, form S-nitrosothiol adducts with vas...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 1993
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.v381435